Aplenzin is available in three strengths: mg, mg, and mg. Wellbutrin XL is available in two strengths: mg and mg. Both medications are taken once a day in the morning, with or without food. Aplenzin and Wellbutrin XL both contain the drug bupropion.
Therefore, both medications can cause very similar side effects. Below are examples of these side effects. This list contains examples of more common side effects that can occur with Aplenzin or Wellbutrin XL when taken individually :.
This list contains examples of serious side effects that can occur with Aplenzin or Wellbutrin XL when taken individually :. In clinical studies , Aplenzin bupropion hydrobromide extended-release has been shown to be very clinically similar to Wellbutrin XL bupropion hydrochloride extended-release. Aplenzin and Wellbutrin XL are both brand-name drugs. Wellbutrin XL has a generic form, but Aplenzin does not. Brand-name medications usually cost more than generics.
According to estimates on GoodRx. Here we look at how Aplenzin and Effexor XR are alike and different. Aplenzin is also approved to prevent depression in people who have seasonal affective disorder SAD. Effexor XR is also approved to treat certain types of anxiety including generalized anxiety disorder, social anxiety disorder also called social phobia , and panic disorder.
Aplenzin contains the active drug bupropion hydrobromide. Effexor XR contains the active drug venlafaxine. Aplenzin comes as a tablet that you swallow. You take it once a day in the morning with or without food. Effexor XR comes as a capsule that you can either swallow or open and pour on a spoonful of applesauce. After swallowing the applesauce, you should drink a glass of water. You take Effexor XR once a day in the morning or evening with food. Both Aplenzin and Effexor XR are extended-release.
Effexor XR is also available in three strengths: Aplenzin and Effexor XR both contain antidepressant medications. These lists contain examples of more common side effects that can occur with Aplenzin, with Effexor XR, or with both drugs when taken individually.
These lists contain examples of serious side effects that can occur with Aplenzin, with Effexor XR, or with both drugs when taken individually. Aplenzin and Effexor XR are both brand-name drugs. Effexor XR has a generic form, but Aplenzin does not. Typically, your doctor will start you on a low dosage. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs. Aplenzin is available in the following strengths: mg, mg, and mg.
For major depressive disorder MDD , your doctor will likely start you on the lowest Aplenzin dose needed. The usual starting dose is mg, once a day in the morning. After taking Aplenzin for 4 days, your doctor will see if your dose needs to be increased.
They may slowly increase your dose to mg, once a day. The slow increase is meant to help prevent seizures. Because seasonal affective disorder SAD usually occurs in the winter season, your doctor will probably start your treatment in the fall. This may help prevent episodes of SAD in winter. The usual starting dose is mg, once a day. After taking Aplenzin for 1 week, your doctor will see if your dose needs to be increased.
Then your doctor will probably start lowering your dose until you stop treatment in early spring. Then keep taking the drug as usual. You can also try using a medication timer. Aplenzin is meant to be used as a long-term treatment. Your doctor will likely monitor your use of Aplenzin. They may adjust your dose or have you stop treatment if needed.
In rare cases , Aplenzin strengthened the effect of alcohol, making people more drowsy, and worsened mental health. Aplenzin can interact with several other medications. It can also interact with certain supplements as well as certain foods.
Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number side effects or make them more severe. Below is a list of medications that can interact with Aplenzin.
Before taking Aplenzin, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.
Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Or your doctor may switch you to a different medication. They may monitor you during your Aplenzin treatment or adjust your Aplenzin dose. Aplenzin blocks an enzyme called CYP2D6. An enzyme is a type of protein.
This enzyme breaks down certain drugs in your body. Taking Aplenzin with drugs that CYP2D6 breaks down can increase the levels of those drugs in your body. They may monitor you during your Aplenzin treatment, lower the dose of your other medication, or switch you to a different medication. Taking Aplenzin may increase your risk for seizures.
Other drugs may also increase your risk for seizures. So taking Aplenzin with these drugs may increase your seizure risk even more. They may monitor you during your Aplenzin treatment, keep you on a lower dose of Aplenzin, or switch you to a different medication.
Drugs called dopaminergics affect a chemical in your body called dopamine. Taking Aplenzin with dopaminergic drugs can cause dopamine to build up to dangerous levels. This can affect your central nervous system , which includes your brain and spinal cord. You may feel dizzy, shaky, nervous, or have trouble walking.
They may monitor you during your Aplenzin treatment, change your dose, or switch you to a different medication. Taking Aplenzin can increase your blood pressure. Other drugs can also increase your blood pressure. So taking Aplenzin with these drugs can increase your risk for high blood pressure.
Your doctor will likely have you stop taking the MAOI at least 14 days before you start using Aplenzin. If this is the case, your doctor will have you stop using Aplenzin 14 days before you start taking an MAOI.
Your doctor may order a different test to check for amphetamine use. However, you should still check with your doctor or pharmacist before using any of these products while taking Aplenzin.
Aplenzin may also be used off-label for other conditions. Aplenzin is used to treat major depressive disorder MDD. These feelings last over a long period of time. Aplenzin is an extended-release drug that contains bupropion hydrobromide. There are no clinical trials that tested the effectiveness of Aplenzin. The FDA approved bupropion hydrobromide based on these studies because it works in a very similar way to bupropion hydrochloride.
In clinical studies of MDD, the immediate-release form of bupropion hydrochloride was found to be more effective than a placebo no treatment. In three short-term studies that lasted 4 to 6 weeks, people took bupropion hydrochloride immediate-release tablets or a placebo. Based on different depression rating scales, bupropion was more effective at treating MDD compared to the placebo. Depending on the study, these scales included the:. A longer study of MDD looked at people who had taken bupropion hydrochloride sustained-release tablets for 8 weeks.
Sustained-release tablets slowly release a steady amount of medication in the body over a long period of time. These results were based whether people needed additional drug treatment due to worsening depression symptoms. Aplenzin is used to prevent episodes of depression in people who have seasonal affective disorder SAD.
Bupropion hydrochloride comes in immediate-, sustained-, and extended-release versions. All these versions and Aplenzin work in a similar way in the body. In clinical studies of SAD, bupropion hydrochloride extended-release tablets were found to be more effective than a placebo no treatment.
They took the drug for about 4 to 6 months and started to lower their dose until they stopped treatment in early spring the end of March. These results were based on whether people developed depression symptoms or needed treatment for depression, and a depression rating score. In addition to the uses listed above, Aplenzin may be used off-label. A review of six clinical studies found that bupropion the active drug in Aplenzin helped decrease ADHD symptoms in adults more than a placebo no treatment.
SSRIs are a type of antidepressant that can cause sexual dysfunction. Aplenzin is approved for use in adults only. In short-term clinical trials , people took various antidepressants, including bupropion the main drug in Aplenzin. If you need financial support to pay for Aplenzin, help is available. Aplenzin comes as a tablet that you take once a day by swallowing it. You can take the medication with or without food in the morning. Make sure the doses are at least 8 hours apart. Doing so can cause your body to absorb the drug too quickly and lead to side effects.
Be sure to swallow the Aplenzin tablet whole with a liquid such as water. Some chemicals in the brain that impact mood are dopamine and norepinephrine. Aplenzin belongs to a drug class called antidepressants. As a result, there are more of these chemicals in the brain, so this helps correct the chemical imbalance. Aplenzin should start working about a week after you start taking it. It takes 8 days to reach a stable level in your body.
In clinical studies , pregnant mothers took bupropion , the active drug in Aplenzin, in the first 3 months of pregnancy. However, more data is needed to confirm whether or not Aplenzin is safe to take during pregnancy.
But other animal studies found that the drug did harm the babies. They can tell you about the pros and cons of using Aplenzin while pregnant compared to the risks of untreated depression.
However, in clinical studies , Aplenzin did pass into breast milk. They can tell you about the pros and cons of using Aplenzin while breastfeeding compared to the risks of untreated depression. In fact, the drug may actually cause you to lose weight. In clinical trials of seasonal affective disorder SAD , people took mg to mg bupropion hydrochloride extended-release tablets each day.
They can review your diet and exercise routine. However, other antidepressants such as sertraline Zoloft may cause sexual problems such as trouble getting an erection, difficulty achieving orgasm, or a lower sex drive. This is because Aplenzin can make these disorders worse and increase your risk for seizures.
If you have a history of eating disorders, talk with your doctor. They may be able to suggest a depression treatment other than Aplenzin. You received your proper dose. After taking Aplenzin, only a very small amount 0. This drug has a boxed warning. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Taking Aplenzin may cause you to have suicidal thoughts and behaviors. Your doctor will monitor you for signs of these during your Aplenzin treatment.
The full antidepressant effect of Aplenzin may not be evident until 4 weeks of treatment or longer. Caution should be taken in patients with hepatic impairment; the dose should not exceed mg every other day, as well as in subjects with renal impairment.
FDA Approval FDA approval of Aplenzin was based on the results of two 4-week, placebo-controlled trials and one 6-week, placebo-controlled trial.
In a longer-term study, outpatients meeting DSM-IV criteria for major depressive disorder, recurrent type, who had responded during an 8-week open trial on bupropion hydrochloride mg twice daily of the sustained-release formulation were randomized to continuation of their same dose of bupropion or placebo, for up to 44 weeks of observation for relapse.
Response during the open phase was defined as CGI Improvement score of 1 very much improved or 2 much improved for each of the final 3 weeks. Patients receiving continued bupropion treatment experienced significantly lower relapse rates over the subsequent 44 weeks compared to those receiving placebo. Adverse events associated with the use of Cimzia may include, but are not limited to, the following:.
Aplenzin is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Psychiatry Research May The Journal of Clinical Psychiatry Feb;68 2 The Journal of Clinical Psychiatry Jun;67 6 Journal of Clinical Psychopharmacology Feb;23 1
0コメント